Every claim we make about the mouth-body connection is built on published science, government reports, and mainstream reporting. This is the library: curated, current, and linked directly to the source.
Eleven RCTs in diabetic patients. Treating periodontitis dropped HbA1c by 0.64% at 3 months and 0.33% at 6 months, with reductions in C-reactive protein, positioning periodontal care as a direct adjunct to diabetes management.
Read the study →Investigative long-read on the historical separation of dentistry from medicine. Profiles integration models: embedded hygienists in medical clinics, combined dental-medical practices, coalitions pushing to "put the mouth back in the body."
Read the article →Veterans Affairs oral-care programs reduced non-ventilator hospital-acquired pneumonia rates by 40–60% and saved hundreds of thousands of dollars per site, positioning oral hygiene as infection control.
Read the toolkit →Public-health framing of oral health as an under-recognized driver of diabetes and cardiovascular outcomes. Urges bidirectional referrals: dental providers screening for diabetes and hypertension, medical providers flagging oral disease.
Read the report →Authoritative patient-facing overview. Oral bacteria and inflammation are linked to heart disease, stroke, premature birth, low birth weight, pneumonia, and worsened diabetes control.
Read the overview →Reviews the evidence that treating periodontal disease may reduce cardiovascular risk, and honestly names the limits of current proof.
Read the article →Patient-accessible summary of the oral-systemic links: heart disease, diabetes, pregnancy complications, pneumonia, and more.
Read the article →Mainstream cardiology recognition. The American Heart Association finds periodontal disease independently associated with coronary heart disease, stroke, and peripheral artery disease, calling for periodontal status in cardiovascular risk assessment.
Read the statement →Functional-medicine framing of the oral microbiome's role in brain health, connecting P. gingivalis to Alzheimer's pathology, and oral-gut microbial crosstalk to rheumatoid arthritis and chronic inflammation.
Read the post →Umbrella review of meta-analyses identified 28 non-communicable diseases strongly associated with oral disease, including 5 cancers, diabetes, cardiovascular disease, depression, neurodegeneration, and inflammatory bowel disease. Echoes the WHO's 2021 call to integrate oral health into primary care.
Read the review →Review of the bidirectional oral–gut microbiome axis: how dysbiosis in the mouth propagates downstream, and how gut imbalance feeds back into oral disease.
Read the study →Landmark 20-year update to the 2000 Surgeon General report. Calls for "integrated oral, medical, and behavioral health care" as national policy: the most authoritative federal endorsement of the oral-systemic model.
Read the report →Porphyromonas gingivalis, the keystone gum disease bacterium, and its gingipain toxins detected in Alzheimer brain tissue. Suggests chronic oral infection as a modifiable risk factor for neurodegeneration.
Read the report →Sweeping review: periodontal disease linked to diabetes, metabolic syndrome, obesity, eating disorders, liver disease, CVD, Alzheimer's, rheumatoid arthritis, adverse pregnancy outcomes, and cancer. Identifies shared genetic, microbial, and immune pathways.
Read the review →Documents successful medical-dental integration programs: prenatal oral health initiatives, geriatric oral care in nursing facilities, co-located dentists in primary clinics. Aligns oral health with patient-centered medical home principles.
Read the report →Pooled observational data confirms periodontal disease is significantly associated with increased lung cancer incidence, implicating chronic oral inflammation in respiratory carcinogenesis.
Read the study →Analysis of 45 studies. The oral pathogen F. nucleatum is roughly 10× more prevalent in colorectal tumor tissue than in normal controls, and high levels correlate with worse survival. A microbial mechanism tying the mouth to distant cancer.
Read the study →Joint workshop of the European Federation of Periodontology and the World Heart Federation. Confirms an independent association between severe periodontitis and CVD, a paradigmatic medical-dental collaboration statement.
Read the consensus →Early functional-medicine summary citing research that P. gingivalis gingipains can travel to the brain and release neuron-damaging toxins implicated in Alzheimer's, reframing oral hygiene as brain hygiene.
Read the post →Early mainstream coverage of the Fusobacterium–colorectal cancer link, and what oral-pathogen translocation might mean for cancer prevention.
Read the article →Academic position paper advocating the integration of oral health into primary care to improve overall health outcomes and reduce system-wide cost.
Read the paper →Explainer on why dental coverage sits apart from medical insurance, and how the structural split reinforces the artificial boundary between mouth and body.
Read the article →Accessible summary of recent findings tying gum infection to increased cardiovascular risk, a patient-friendly on-ramp to the AHA and Sanz et al. literature above.
Read the article →This library is updated as new evidence lands. If you're a clinician or researcher and want a paper added to the review, write us. We'd rather our science keep growing than settle.